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1993 3
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2002 7
2003 13
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128 results

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Page 1
Targeting ROS and cPLA2/COX2 Expressions Ameliorated Renal Damage in Obese Mice with Endotoxemia.
Chang JF, Yeh JC, Ho CT, Liu SH, Hsieh CY, Wang TM, Chang SW, Lee IT, Huang KY, Wang JY, Lin WN. Chang JF, et al. Int J Mol Sci. 2019 Sep 6;20(18):4393. doi: 10.3390/ijms20184393. Int J Mol Sci. 2019. PMID: 31500176 Free PMC article.
Furthermore, inhibitors of nonspecific ROS, cPLA2 and COX-2 ameliorated the above renal damages. Notably, the ROS-inhibitor-treated group ameliorated not only oxidative injury but also the expression of cPLA2 and COX-2, indicating that ROS functions as the upstream …
Furthermore, inhibitors of nonspecific ROS, cPLA2 and COX-2 ameliorated the above renal damages. Notably, the ROS-inhibitor-treated g …
Glucocorticoids use in kidney transplant setting.
De Lucena DD, Rangel ÉB. De Lucena DD, et al. Expert Opin Drug Metab Toxicol. 2018 Oct;14(10):1023-1041. doi: 10.1080/17425255.2018.1530214. Epub 2018 Oct 5. Expert Opin Drug Metab Toxicol. 2018. PMID: 30265586 Review.
INTRODUCTION: Despite major advances in kidney transplant, glucocorticoids (GCs) or steroids remain one of the mainstay treatments. ...Some clinically relevant drug-drug interactions are also highlighted. Expert opinion: Although SA/SW in kidney transplant is a desi …
INTRODUCTION: Despite major advances in kidney transplant, glucocorticoids (GCs) or steroids remain one of the mainstay treatments. . …
Arachidonic Acid as Mechanotransducer of Renin Cell Baroreceptor.
Das UN. Das UN. Nutrients. 2022 Feb 10;14(4):749. doi: 10.3390/nu14040749. Nutrients. 2022. PMID: 35215399 Free PMC article. Review.
Cell shape changes in response to external pressure(s) result(s) in the activation of cPLA2 (cytosolic phospholipase 2)-AA pathway that stretches to recruit myosin II which produces actin-myosin cytoskeleton contractility. ...
Cell shape changes in response to external pressure(s) result(s) in the activation of cPLA2 (cytosolic phospholipase 2)-AA pathway th …
Therapeutic potential of cPLA2 inhibitor to counteract dilated-cardiomyopathy in cholesterol-treated H9C2 cardiomyocyte and MUNO rat.
Huang JP, Cheng ML, Wang CH, Huang SS, Hsieh PS, Chang CC, Kuo CY, Chen KH, Hung LM. Huang JP, et al. Pharmacol Res. 2020 Oct;160:105201. doi: 10.1016/j.phrs.2020.105201. Epub 2020 Sep 15. Pharmacol Res. 2020. PMID: 32942017
The effects of cholesterol-mediated LysoPCs on cardiac injury, and the action of cPLA2 inhibitor, AACOCF3, were further assessed in H9C2 cardiomyocytes. ...CONCLUSION AND IMPLICATIONS: Cholesterol-induced MUNO-DCM phenotype was counteracted by cPLA2 inhibitor, which …
The effects of cholesterol-mediated LysoPCs on cardiac injury, and the action of cPLA2 inhibitor, AACOCF3, were further assessed in H …
Regulation of rat kidney mesangial cell phospholipase A2.
Hack N, Tay A, Schultz A, Muzin N, Clayman P, Egan S, Skorecki KL. Hack N, et al. Clin Exp Pharmacol Physiol. 1996 Jan;23(1):71-5. Clin Exp Pharmacol Physiol. 1996. PMID: 8713499 Review.
Eicosanoids have diverse physiological and pathophysiological effects in the kidney. The regulation of phospholipase A2 has important implications for kidney function. 2. ...At the post-translational level, using site directed mutagenesis of cPLA2 and a domin …
Eicosanoids have diverse physiological and pathophysiological effects in the kidney. The regulation of phospholipase A2 has important …
Endoplasmic-reticulum-stress-induced lipotoxicity in human kidney epithelial cells.
Çeker T, Yılmaz Ç, Kırımlıoglu E, Aslan M. Çeker T, et al. Toxicol Res (Camb). 2022 Jul 22;11(4):683-695. doi: 10.1093/toxres/tfac041. eCollection 2022 Aug. Toxicol Res (Camb). 2022. PMID: 36051659 Free PMC article.
Accumulation of lipids and their intermediary metabolites under endoplasmic reticulum (ER) stress instigates metabolic failure, described as lipotoxicity, in the kidney. This study aimed to determine ER-stress-related sphingolipid and polyunsaturated fatty acid (PUFA) chan …
Accumulation of lipids and their intermediary metabolites under endoplasmic reticulum (ER) stress instigates metabolic failure, described as …
cPLA2-interacting protein, PLIP, causes apoptosis and decreases G1 phase in mesangial cells.
Muckova K, Duffield JS, Held KD, Bonventre JV, Sheridan AM. Muckova K, et al. Am J Physiol Renal Physiol. 2006 Jan;290(1):F70-9. doi: 10.1152/ajprenal.00358.2004. Epub 2005 Jun 28. Am J Physiol Renal Physiol. 2006. PMID: 15985650 Free article.
The regulation of cell proliferation and apoptosis is linked at the level of the cell cycle (Shankland SJ. Kidney Int 52: 294-308, 199). cPLA2-interacting protein (PLIP), the Tip60 splice variant, interacts with cPLA2 and enhances the susceptibility of renal …
The regulation of cell proliferation and apoptosis is linked at the level of the cell cycle (Shankland SJ. Kidney Int 52: 294-308, 19 …
Cross-talk between cytosolic phospholipase A2 alpha (cPLA2 alpha) and secretory phospholipase A2 (sPLA2) in hydrogen peroxide-induced arachidonic acid release in murine mesangial cells: sPLA2 regulates cPLA2 alpha activity that is responsible for arachidonic acid release.
Han WK, Sapirstein A, Hung CC, Alessandrini A, Bonventre JV. Han WK, et al. J Biol Chem. 2003 Jun 27;278(26):24153-63. doi: 10.1074/jbc.M300424200. Epub 2003 Apr 3. J Biol Chem. 2003. PMID: 12676927 Free article.
Mitochondrial oxidative damage reprograms lipid metabolism of renal tubular epithelial cells in the diabetic kidney.
Hou Y, Tan E, Shi H, Ren X, Wan X, Wu W, Chen Y, Niu H, Zhu G, Li J, Li Y, Wang L. Hou Y, et al. Cell Mol Life Sci. 2024 Jan 11;81(1):23. doi: 10.1007/s00018-023-05078-y. Cell Mol Life Sci. 2024. PMID: 38200266 Free PMC article.
The functional and structural changes in the proximal tubule play an important role in the occurrence and development of diabetic kidney disease (DKD). Diabetes-induced metabolic changes, including lipid metabolism reprogramming, are reported to lead to changes in the stat …
The functional and structural changes in the proximal tubule play an important role in the occurrence and development of diabetic kidney …
Dietary soy protein selectively reduces renal prostanoids and cyclooxygenases in polycystic kidney disease.
Peng CY, Sankaran D, Ogborn MR, Aukema HM. Peng CY, et al. Exp Biol Med (Maywood). 2009 Jul;234(7):737-43. doi: 10.3181/0811-RM-315. Epub 2009 May 8. Exp Biol Med (Maywood). 2009. PMID: 19429858
Diseased kidneys had elevated protein and mRNA levels of cytosolic phospholipase A(2) (cPLA(2)) and COX1 and lower levels of COX2. Dietary soy protein attenuated the protein levels of cPLA(2) in diseased kidneys, and reduced COX2 mRNA expression in both normal and d …
Diseased kidneys had elevated protein and mRNA levels of cytosolic phospholipase A(2) (cPLA(2)) and COX1 and lower levels of COX2. Di …
128 results